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ACE2 Antibody
ACE2 Antibody
产品编号: 3217
规  格:
单  价: 询价
生 产 商: ProSci
到货时间: 2-3weeks
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BACKGROUND
ACE2 Antibody: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

ALTERNATE NAMES
ACE2 Antibody: ACEH, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACEH

CONJUGATE
Unconjugated

PURIFICATION
ACE2 Antibody is affinity chromatography purified via peptide column.

HOST SPECIES
Rabbit

CLONALITY
Polyclonal

ISOTYPE
IgG

IMMUNOGEN
ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2.

TESTED APPLICATIONS
E, WB, IHC, IF

APPLICATIONS
ACE2 antibody can be used for the detection of ACE2 by Western blot at 0.5 to 2 μg/mL. A 90 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL.

BUFFER
ACE2 Antibody is supplied in PBS containing 0.02% sodium azide.

STORAGE CONDITIONS
ACE2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

SPECIES REACTIVITY
Human

 

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